Summary of product characteristics.
Cobactan® LC (in UK: Cephaguard® Milking Cow)
|Composition||per 8g syringe|
(as cefquinome sulphate)
Intramammary ointment in prefilled syringes.
Pharmaceutic group: Cephalosporins and related substances
ATCvet code: QJ51DA92.
Cefquinome is an antibacterial drug of the cephalosporin group which acts by inhibition of cell wall synthesis. It is characterised by its broad therapeutic spectrum of activity and a high stability against beta-lactamases.
In vitro, Cefquinome has antibiotic activity against common Gram negative and Gram positive bacteria including Escherichia coli, Staphylococcus aureus, Streptococcus dysgalactiae, Streptococcus agalactiaeand Streptococcus uberis.
After intramammary administration, a mean concentration of 19 mcg/ml in milk is observed 12 hours post last infusion. The highest MIC 90 value was found for Staphylococcus aureus. This pathogen has a MIC 90 in the range of 1 µg/ml.
At the second milking following the last infusion the mean concentration is still approximately 2.5 mcg/ml and then falls to 0.75 mcg/ml at the third milking post last infusion.
Resorption of cefquinome from the udder is insignificant.
For the treatment of clinical mastitis in the lactating dairy cow caused by the following cefquinome-sensitive organisms : Streptococcus uberis, Streptococcus dysgalactiae, Staphylococcus aureus and Escherichia coli.
Not to be administered to animals which are known to be hypersensitive to cephalosporin antibiotics and other β-lactam antibiotics.
Do not use the cleaning towel on lesioned teat.
Cephaguard® Milking Cow is intended for use during lactation. There is no available information indicating reproductive toxicity (inc. teratogenicity) in cattle. In reproductive toxicity studies in laboratory animals cefquinome did not reveal any effect on reproduction or teratogenic potential.
It is known that a cross sensitivity to cephalosporins exits for bacteria sensitive to the cephalosporin group.
The content of one syringe should be infused gently into the teat of the infected quarter every 12 hours after each of three successive milkings.
Milk out the affected quarter(s). After thoroughly cleaning and disinfecting the teat and teat orifice with the cleaning towel provided, gently infuse the contents of one syringe into each affected quarter. Disperse the product by gentle massage of the teat and udder of the affected animal.
No symptoms expected or emergency procedures required.
Meat = 4 days
Milk = 5 days
Penicillins and cephalosporins may cause hypersensitivity (allergy) following injection, inhalation, ingestion or skin contact. Hypersensitivity to penicillins may lead to cross sensitivity to cephalosporin and vice versa. Allergic reactions to these substances may occasionally be serious.
Wash hands after using the wipes and wear protective gloves if skin irritation due to Isopropyl alcohol is known or suspected.
The syringe must only be used once. Part used syringes should be discarded.
Do not store above 30°C.
White opaque polyethylene syringes and cleaning towels in paper aluminium copolymer laminate sachet.
Packs of 3, 15, 20 and 24 syringes and cleaning towels.
Not all pack sizes may be marketed.
Any unused product or waste material should be disposed of in accordance with national requirements.