Cobactan LA ^7.5% - description

Name: Cobactan LA^7.5%, Suspension for injection.

Active substance: Cefquinome (as sulphate): 75 mg/ml

Indications for use: For the treatment of bovine respiratory disease (BRD) associated with Mannheimia haemolytica, Pasteurella multocida and Histophilus somni sensitive to cefquinome.

Amounts to be administered and administration routes: Two subcutaneous injections of 2.5 mg Cefquinome / kg bodyweight (equivalent to 1 ml/30 kg bodyweight) with a 48 hour interval.

Withdrawal period: Cattle (meat and offal): 13 days Do not use within two months prior to first calving in heifers intended for the production of milk for human consumption.

Pharmacodynamic properties: Cefquinome is an antibacterial of the cephalosporin group which acts by inhibition of cell wall synthesis. It is characterised by its broad therapeutic spectrum of activity. As a fourth generation cephalosporin, it combines high cellular penetration and a high stability against beta-lactamases.

In vitro activity has been demonstrated against common Gram positive and Gram negative bacteria including Mannheimia haemolytica, Pasteurella spp., Histophilus somni, Escherichia coli, Citrobacter spp., Klebsiella spp,, Proteus spp., Salmonella spp., Serratia marcescens, Arcanobacterium pyogenes, Corynebacterium spp., Staphylococcus aureus, coagulase negative Staphylococci, Streptococcus dysgalactiae, Streptococcus agalactiae, Streptococcus uberis, Streptococcus bovis.

A total of 207 Pasteurella multocida, 131 Mannheimia haemolytica and 19 Histophilus somni isolated between 2000 and 2004 from the respiratory tract of diseased cattle in Belgium, France, Germany, Italy, Ireland, the Netherlands and the United Kingdom were investigated. The MIC₉₀ for Pasteurella multocida and Mannheimia haemolytica strains was 0.032 µg/ml, whereas the MIC-value determined for all of the Histophilus somni strains was 0.004 μg/ml.

Contraindications: Not to be administered to animals which are known to be hypersensitive to cephalosporin antibiotics or other ß-lactam antibiotics.