Cobactan LA^7.5% - efficacy under field conditions

Treatment failure in cattle suffering from pneumonia often leads to irreversible lung tissue damage. Therefore it is essential to assess the efficacy as early as possible.

Efficacy trial – Early assessment of the success of treatment of bovine pneumonia with Cobactan^7.5%

Method

• Animals showing signs of bovine respiratory disease (BRD)
  (rectal temperature ≤ 40°C, impaired respiration and depression) were enrolled into the study.
• Animals were treated with Cobactan^7.5% once or twice (48 hours apart). The necessity of 2nd treatment was based on the clinical response and the severity of symptoms after 48 hours.
• An assessment of treatment efficacy was made on Day 5.

Result

Conclusion

The study demonstrates that animals showing an improvement of clinical signs on Day 2 after treatment are cured without a second treatment. Those not clinically improved on Day 2 received a second treatment and recovered. The severity of clinical signs is a reliable predictor for the treatment effect on Day 5.

Efficacy trial - Comparison to ceftiofur

A field study to confirm the efficacy of Cobactan^7.5% against bovine respiratory disease (BRD) was carried out in The Netherlands and Germany. The clinical efficacy of Cobactan^7.5% was compared to that of another product containing the active ingredient ceftiofur. Ceftiofur is well established for the treatment of BRD.

Method

242 Cattle showing clinical signs of BRD were divided into two groups. Laboratory tests confirmed the presence of concomitant viral, mycoplasma and bacterial infections.

• Group 1– treated with Cobactan^7.5% (2,5 mg/kg body weight, subcutaneously). In cases where the response to treatment was not adequate, a second dose was administered two days later.
• Group 2– Ceftiofur product was given for three consecutive days (1mg/kg body weight). In cases where the response to treatment was not adequate, treatment was extended to five days.

Clinical examinations were carried out daily until 12 days after initial inclusion in the study.

Primary efficacy criterion was the overall treatment success rate on day 12.

• All animals with a body temperature <40ºC
• Normal or mild abnormal respiration.
• No depression

Secondary criteria were:

• Intermediate treatment success (day 5)
• Relapse rate (day 6 - 12
• Mortality (day 0-12)
• Daily weight gain (day 0-21)

Overall treatment success rate

Intermediate treatment success rate

Conclusion

Cobactan^7.5% given at a dosage of 2,5 mg/kg bw as one or two injections 48 hours apart is as successful as ceftiofur given in 3-5 injections 24 hours apart with regard to overall treatment success.

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